幽门螺杆菌感染与大肠癌的关系分析

摘要

ObjectiveTo explore the relationship between Helicobacter pylori (Hp) and colorectal cancer, and provide a theoretical basis for the prevention of colorectal cancer.MethodSelected our hospital from March 2013 to March 2014 conifrmed 40 patients with colorectal cancer as colorectal cancer group, selected 40 cases of endoscopic examination showed normal colorectal mucosa as control group. Compared Hp infection status of the two groups of patients and Hp infection rate of different pathological types of colorectal cancer patients.ResultThe Hp infection rate, COX-2 positive rate in control group were signiifcantly lower than colorectal cancer group (P<0.05). There was no significant difference in Hp infection rate among different pathological types of colorectal cancer patients (P>0.05). Logistic regression analysis showed that Hp infection was a risk factor for colorectal cancer (P<0.05).ConclusionHp infection may increase the incidence of colorectal cancer by up regulating COX-2 expression.%目的：探究幽门螺杆菌（Hp）与大肠癌的相关性，为预防大肠癌提供理论依据。方法选取本院2013年3月至2014年3月确诊的40例大肠癌患者作为大肠癌组，另选取同期40例经肠镜检查显示大肠黏膜正常者作为对照组。比较两组研究对象Hp感染状况及不同病理类型大肠癌患者Hp感染率。结果对照组Hp感染率、环氧合酶-2（COX-2）阳性率均显著低于大肠癌组（P＜0.05）。不同病理类型大肠癌患者Hp感染率比较差异均无显著性（P＞0.05）。非条件Logistic回归分析表明，Hp感染是大肠癌发生的危险因素。结论 Hp感染可能通过上调COX-2表达导致大肠癌的发生率增加。