乌司他丁辅助治疗对脓毒症患者血清NT-proBNP和心肌酶的影响分析

摘要

目的 探讨乌司他丁辅助治疗对脓毒症患者血清氨基酸末端B型利钠肽前体(N-terminal pro-B-type natriuretic peptide,NT-proBNP)和心肌酶水平的影响.方法 采用随机数表法将本院2015年1月至2016年12月接诊的180例脓毒症患者分为试验组和对照组,每组各90例.对照组患者给予血必净注射液治疗,试验组患者在对照组治疗基础上辅助应用乌司他丁注射液治疗,两组患者均连续治疗1周.比较两组患者治疗前后血压、心率、急性生理功能与慢性健康状况评分系统Ⅱ(acute physiology and chronic health evaluationⅡ,APACHEⅡ)评分及炎性因子、血清NT-proBNP、心肌酶水平.结果 治疗后试验组患者心率、C反应蛋白、白介素-6、肿瘤坏死因子-α、心肌肌钙蛋白I、乳酸脱氢酶、肌酸激酶同工酶、NT-proBNP水平及APACHEⅡ评分均显著低于对照组(P<0.05),血压显著高于对照组(P<0.05).结论 乌司他丁辅助治疗脓毒症,对于降低心肌酶指标、血清NT-proBNP及炎性因子水平均具有显著效果,值得推广应用.%Objective To investigate the effects of Ulinastatin adjuvant therapy on serum N-terminal pro-B-type natriuretic peptide (NT-proBNP) and myocardial enzymes in patients with sepsis.Method 180 cases of sepsis patients in our hospital from January 2015 to December 2016 were randomly divided into experimental group and control group, 90 cases in each group. Patients in control group were treated with Xuebijing injection. Patients in experimental group were treated with Ulinastatin injection on the basis of control group, and both groups were treated continuously for 1 week. The blood pressure, heart rate, acute physiology and chronic health evaluationⅡ (APACHEⅡ) scores and the levels of inflammatory cytokines, serum NT-proBNP, myocardial enzyme were compared between the two groups.Result The heart rate, levels of C-reactive protein, interleukin-6, tumor necrosis factor-α, cardiac troponin I, lactate dehydrogenase, creatine kinase isoenzyme, NT-proBNP and APACHEⅡ score in experimental group were significantly lower than control group (P<0.05), the blood pressure was significantly higher than control group (P<0.05). ConclusionUlinastatin adjuvant treatment of sepsis, for reducing the levels of myocardial enzyme index, NT-proBNP and inflammatory cytokines have a significant effect, suitable for promotion.