糖皮质激素冲击治疗对女性系统性红斑狼疮患者代谢及免疫功能的影响分析

摘要

Objective To investigate the effect of glucocorticoid pulse treatment on metabolism and immune function in female patients with systemic lupus erythematosus (SLE). Method 142 female SLE patients in our hospital from June 2013 to June 2016 were randomly divided into observation group and control group, 71 cases in each group. Observation group patients received glucocorticoid pulse treatment, control group patients received conventional glucocorticoid treatment. The changes of metabolism and immune function were compared between the two groups before and after treatment, and the adverse reactions were observed. Result After treatment, the metabolic indexes of observation group were more significant than control group (P<0.05). After treatment, the levels of immunoglobulin (Ig) A, IgG and IgM in the two groups were significantly lower than those before treatment (P<0.05), and the levels of C3 and C4 were significantly higher than those before treatment (P < 0.05). The levels of IgA, IgG and IgM in observation group were significantly lower than control group (P<0.05), and the levels of C3 and C4 were significantly higher than control group (P<0.05). The incidence of adverse reactions in observation group was 32.39%, control group was 29.58%, the incidence of adverse reactions between the two groups was not statistically significant (P > 0.05). Conclusion Glucocorticoid pluse treatment can promote the correction of the related metabolic indicators and improve the immune function of female patients with SLE on the basis of ensuring the safety of treatment.%目的 分析糖皮质激素冲击治疗对女性系统性红斑狼疮(systemic lupus erythematosus,SLE)患者代谢及免疫功能的影响,探讨其临床应用价值. 方法 选取本院2013年6月至2016年6月收治的142例女性SLE患者为研究对象,按照随机数表法将入选患者分为观察组和对照组,每组各71例.观察组患者接受糖皮质激素冲击治疗,对照组患者接受糖皮质激素常规治疗.比较两组患者治疗前后代谢指标和免疫功能变化情况,并观察不良反应发生情况.结果 观察组患者治疗后疗效相关代谢指标较对照组改善更显著(P<0.05).两组患者治疗后免疫球蛋白(immunoglobulin,Ig)A、IgG、IgM水平均显著低于治疗前(P<0.05),C3和C4水平均显著高于治疗前(P<0.05);观察组患者治疗后IgA、IgG、IgM水平均显著低于对照组(P<0.05),C3和C4水平均显著高于对照组(P<0.05).观察组不良反应发生率为32.39%,对照组为29.58%,两组患者率比较无显著差异(P>0.05).结论糖皮质激素冲击治疗能够在保证治疗安全的基础上,能够促进女性SLE患者疗效相关代谢指标的纠正与免疫功能的改善.