牙周牙髓联合治疗对重度牙周炎患者牙周组织基质金属蛋白酶表达及预后的影响分析

摘要

Objective To analyze the effect of combined periodontal endodontic treatment on the expression of matrix metalloproteinase (MMP) and prognosis in periodontal tissues of patients with severe periodontitis, and to explore its clinical application value. Method In our hospital from February 2014 to February 2016, 180 cases of severe periodontitis patients were randomly divided into observation group and control group, 90 cases in each group. Observation group patients were given combined periodontal endodontic treatment, and control group patients were given simple periodontal treatment. Compared the prognosis of the two groups and the changes of periodontal tissue MMP, and analyzed the effect and mechanism of combined periodontal endodontic treatment of severe periodontitis. Result The total efficiency of observation group was significant higher than control group (χ2= 6.527, P 0.05). Conclusion Combined periodontal endodontic treatment scheme can effectively reduce the severe periodontitis patients undergoing periodontal tissue MMP-1, MMP-8 expression levels, in order to effectively improve the clinical curative effect in treatment of security under the premise, it is worthy of popularization and application.%目的 分析牙周牙髓联合治疗对重度牙周炎患者牙周组织基质金属蛋白酶(matrix metallo-proteinase,MMP)表达及预后的影响,探讨其临床应用价值.方法 选取本院2014年2月至2016年2月收治的180例重度牙周炎患者为研究对象.按照随机数表法将入选患者分为观察组和对照组,每组各90例.观察组患者给予牙周牙髓联合治疗,对照组患者给予单纯牙周治疗.对比两组患者预后及牙周组织MMP变化,分析牙周牙髓联合治疗重度牙周炎的效果与机制.结果 观察组患者临床治疗总有效率显著高于对照组(χ2=6.527,P0.05).结论 牙周牙髓联合治疗能够有效降低重度牙周炎患者牙周组织MMP-1和MMP-8表达水平,从而在保证治疗安全性的前提下有效提高临床疗效,值得推广应用.