Effect of reinforced flowable resin restoration on periodontal tissue in patients with severe periodontitis and anterior tooth loss

摘要

Objective:To study the effect of traditional flowable resin and reinforced flowable resin restoration on periodontal tissue in patients with severe periodontitis and anterior tooth loss. Methods: A total of 76 patients with severe periodontitis and anterior tooth loss who received treatment in our hospital from May 2012 to October 2015 were selected and randomly divided into reinforced group and traditional group who received reinforced flowable resin restoration and traditional flowable resin restoration respectively. Inflammation indexes, oxidative stress indexes, bone metabolism indexes and apoptotic indexes in gingival crevicular fluid were compared between two groups.Results:2 weeks after treatment, NLRP3, IL-1β, IL-18, RANKL, MDA, O2-, H2O2, Fas, FasL, Bax, Smac, Apaf-1 and Caspase-3 levels as well as caspase-1 vitality in gingival crevicular fluid of reinforced group were significantly lower than those of traditional group while SOD, GSH-Px, OPG, ALP, Runx2, OCN and Col-1 levels were significantly higher than those of traditional group.Conclusion: Reinforced flowable resin restoration can alleviate inflammation and oxidative stress in periodontal tissue, and inhibit alveolar bone resorption and cell apoptosis in patients with severe periodontitis and anterior tooth loss.