前列地尔对急性心肌梗死患者左室重构的影响

摘要

目的 探讨前列地尔对急性心肌梗死患者左室重构的影响.方法 选择2015年6月至2016年6月本院接收的152例急性心肌梗死患者为研究对象,按照双盲数字法将入选患者分为对照组和观察组,每组各76例.两组患者均采用冠心病常规疗法治疗,观察组患者在上述治疗基础上联合前列地尔注射液治疗,连续治疗21天.比较两组患者治疗前及治疗7天、21天后左室收缩末期内径(left ventricular end-systolic diameter,LVESd)、左室舒张末期内径(left ventricular end-diastolic diameter,LVEDd)、左室后壁舒张末期内径(left ventricular posterior wall end-diastolic,LVPWd)、射血分数(ejection fraction,EF)、心房舒张早期充盈最大速率(E峰)与心房收缩期最大充盈速率(A峰)流速比值(E/A)及疗效.结果 治疗7天、21天后,两组患者LVEDd和LVESd均显著小于治疗前(P<0.05),观察组患者LVEDd和LVESd均显著小于对照组(P<0.05);两组患者治疗前后LVPWd均无显著变化(P>0.05).治疗7天、21天后,观察组患者EF均显著低于对照组(P<0.05),E/A和治疗总有效率均显著高于对照组(P<0.05).结论 前列地尔辅助治疗急性心肌梗死,能够有效降低LVEDd、LVESd、EF,提高E/A和疗效,减少患者左室重构,改善心功能.%Objective To investigate the effect of Alprostadil on left ventricular remodeling in patients with acute myocardial infarction. Method 152 patients with acute myocardial infarction in our hospital from June 2015 to June 2016 were randomly selected and divided into control group and observation group, 76 cases in each group. Two groups of patients were treated with conventional coronary heart disease, observation group patients were treated with Alprostadil on the basis of the above treatment, continuous treatment for 21 days. Before and after 7 days and 21 days treatment, the left ventricular end systolic diameter (LVESd), left ventricular end diastolic diameter (LVEDd), left ventricular posterior wall end diastolic diameter (LVPWd), ejection fraction (EF), early diastolic atrial maximum velocity (E peak) and atrial systolic peak filling rate (A peak) and the effect of velocity ratio (E/A) were detailed recorded and compared between the two groups. The curative effect was counted 21 days after treatment. Result After 7 days and 21 days treatment, the LVEDd and LVESd of the two groups were significantly less than those before treatment (P<0.05). The LVEDd and LVESd in observation group were significantly less than control group (P<0.05). There was no significant changes of LVPWd between the two groups before and after treatment (P>0.05). After treatment for 7 days and 21 days, the EF of observation group was significantly lower than control group (P<0.05), the curative effect and E/A were significantly higher than control group (P<0.05). Conclusion The use of Alprostadil in the treatment of acute myocardial infarction can effectively reduce the levels of the LVEDd, LVESd, EF, improve E/A and curative effect, reduce left ventricular remodeling, improve cardiac function.