152例术后非小细胞肺癌患者预后相关因素分析

摘要

Objective To analyze the relationship between miRNA-21, miRNA-155, clinicopathological characteristics and prognosis among resected non-small cell lung cancer (NSCLC) patients. Method Analyzed the clinical and laboratory characteristics of 152 patients with NSCLC. Expression of miRNA-21 and miRNA-155 of the embedded tissue of the patients were detected by quantitative real-time polymerase chain reaction. Other clinicopathological characteristics were also collected. Result Univariate analysis identified significant prognostic clinical factors including age, stage, miRNA-21 expression, tumor size (P < 0.05). In multivariate analysis, age (HR = 1.027; 95%CI: 1.005 ~ 1.049), TNM stage: stage Ⅱ (HR =2.379; 95%CI: 1.385 ~ 4.086) and stage Ⅲ (HR = 2.521; 95%CI: 1.440 ~ 4.414), miRNA-21 expression increased in cancer tissues (HR = 1.149; 95%CI: 1.055 ~ 1.250) were independent prognostic factors. Conclusion Age, TNM stage: stage Ⅱ and Ⅲ , miRNA-21 increased in cancer tissues have the prognostic significance in postoperative NSCLC patients.%目的 探讨微小RNA(miRNA)-21与miRNA-155的表达水平及临床病理学特征与术后非小细胞肺癌(non-small cell lung cancer,NSCLC)患者预后的相关性.方法 采用实时荧光定量聚合酶链反应检测152例NSCLC患者术后石蜡包埋组织标本中miRNA-21、miRNA-155的表达水平,采用单因素和多因素分析miRNA-21与miRNA-155表达水平、临床病理学特征与预后的相关性.结果 单因素分析显示,与术后NSCLC患者预后相关的因素包括:年龄、肿瘤大小、miRNA-21表达水平、TNM分期(P<0.05);多因素分析显示:年龄大(HR=1.027;95%CI:1.005~1.049)、TNM分期为Ⅱ期(HR=2.379;95%CI:1.385~4.086)和Ⅲ期(HR=2.521;95%CI:1.440~4.414)、癌组织中miRNA-21表达水平升高(HR=1.149;95%CI:1.055~1.250)是影响术后NSCLC患者预后的独立危险因素.结论 年龄大、TNM分期为Ⅱ期和Ⅲ期、癌组织中miRNA-21表达水平升高是术后NSCLC患者预后的独立危险因素.