复方磺胺甲恶唑片联合胸腺肽治疗AIDS合并PCP的临床疗效及其对血清炎性因子和乳酸脱氢酶的影响

摘要

目的 探讨复方磺胺甲恶唑片联合胸腺肽治疗获得性免疫缺陷综合征(acquired immunodeficiency syndrome, AIDS)合并肺孢子菌肺炎(pneumocystis pneumonia,PCP)的临床疗效及其对血清炎性因子和乳酸脱氢酶(serum lactate dehydrogenase,LDH)表达水平的影响.方法 选取本院2016年2月至2017年2月收治的临床资料完整的130例AIDS合并PCP患者为研究对象,按随机数表法将其分为对照组与观察组,每组各65例.两组患者均给予平衡电解质、高蛋白饮食、吸氧等常规治疗.对照组患者在常规治疗基础上给予复方磺胺甲恶唑片治疗,观察组患者在对照组治疗基础上联合胸腺肽治疗,两组患者均连续治疗14天.比较两组患者的临床疗效、不良反应发生情况、LDH及血清炎性因子表达水平.结果 观察组患者治疗总有效率显著高于对照组(P<0.05).两组患者不良反应发生率比较无显著差异(P>0.05).治疗后7天和14天,两组患者血清LDH、白介素(interleukin,IL)-1、IL-6、IL-10表达水平均显著低于治疗前(P<0.01),且观察组患者上述指标表达水平均显著低于对照组(P<0.01);治疗后14天,两组患者上述指标表达水平均显著低于治疗后7天(P<0.01).结论 复方磺胺甲恶唑片联合胸腺肽治疗AIDS合并PCP,可明显减轻患者机体炎性反应,治疗效果好,安全性高.%Objective To explore the curative efficacy of Compound sulfamethoxazole tablets combined with Thymosin in the treatment of acquired immunodeficiency syndrome (AIDS) patients combined with pneumocystis pneumonia (PCP) and its effects on inflammatory factors in serum. Method From February 2016 to February 2017, 130 AIDS patients combined with PCP treated in our hospital were selected as the study objects, and they were divided into control group and observation group according to the random number table method, 65 cases in each group. Two groups of patients were given balanced electrolytes, high protein diet, oxygen inhalation, bed rest and other conventional treatment. Control group patients were given Compound sulfamethoxazole tablets on the basis of the routine treatment, and observation group patients were given Thymosin on the basis of control group, all the patients were treated for 14 days continuously. The curative efficacy, adverse reaction and the levels of inflammatory factors in serum of the two groups were compared. Result The total curative efficacy of observation group was significantly higher than that of control group (P < 0.05). There was no significant difference in advevse reaction between the two groups (P > 0.05). 7 days and 14 days after treatment, the levels of serum lactate dehydrogenase (LDH), interleukin (IL)-1, IL-6 and IL-10 in the two groups were significantly lower than those of before treatment (P<0.01), and the levels of the above indicators of observation group were significantly lower than those of control group (P<0.01); 14 days after treatment, the levels of above indicators of the two groups were significantly lower than those of 7 days after treatment (P<0.01). Conclusion Compound sulfamethoxazole tablets combined with Thymosin can reduce the inflammatory response of patients with AIDS combined with PCP, and it has good curative efficacy and higher security.