IVF-ET中不同年龄卵巢储备功能减退女性应用生长激素的效果分析

摘要

Objective:To investigate the influence on outcomes of different age women with diminished ovarian reserve (DOR) treated by growth hormone(GH) combined within GnRH antagonist protocol when undergone in vitro fertilization and embryo transfer(IVF-ET).Methods:A total of 131 women with DOR were enrolled into this study,which ineluded 69 women less than 35 years old and 62 women equal to or over 35 years old.All included women received the antagonist protocol.In order to observe the effect of GH on ovarian response and pregnancy outcome for different age women,women had used GH were in GH group,and women hadn't used GH were in control group.Results:As for women with equal to or over 35 years old,the dosage of GH used of women in GH group was significantly lower than that of women in control group.Level of E2 and number of collected oocytes of women on the day of HCG administra tion had significantly increased compared to women in control group (P＜0.05).As for women less than 35 years old,there were no significant differences in clinical data and laboratory data.Conclusion:GH combine with a GnRH antagonist protocol could improve the ovarian response for equal to or over 35 years old women with diminished ovarian reserve,while there was no significant effect for women less than 35 years old.%目的:探讨生长激素(GH)联合拮抗剂方案对不同年龄卵巢储备功能减退(DOR)患者体外受精一胚胎移植(IVF-ET)结局的影响.方法:行IVF-ET治疗的卵巢储备功能减退的不孕患者131人,其中年龄≥35岁62人,年龄＜35岁69人,均采用拮抗剂方案,以添加GH为GH组,不添加GH者为对照组,观察不同年龄组内添加GH后的卵巢反应性和妊娠结局.结果:年龄≥35岁的DOR患者GH组与对照组相比,Gn的使用剂量明显减少,hCG日雌二醇(E2)水平、获卵数均增高(P均＜0.05);年龄＜35岁的DOR患者,GH组与对照组间各项临床及实验室指标比较均无统计学差异(P＞0.05).结论:GH联合拮抗剂方案可以改善年龄≥35岁DOR患者IVF-ET过程中卵巢的反应性;而对年龄＜35岁DOR患者的卵巢反应及IVF-ET结局均无明显改善.