膦甲酸钠联合阿昔洛韦对复发性生殖器疱疹患者免疫功能的影响

摘要

Objective:To explore the effect of foscarnet sodium combined with acyclovir on the immune function of patients with recurrent genital herpes.Methods:94 patients with recurrent genital herpes were divided into observation group and control group (47 cases in each group).Patients in control group were treated by acyclovir,and patients in observation group were treated by foscarnet sodium combined with acyclovir.Before and after treatment,the levels of serum CD4,CD8,CD4/CD8,NK cells,interleukin 4 (IL-4) and interferon gamma (IFN-γ),IFN-γ/IL-4 were detected.After followed up for 6 months,the recurrence frequency and the skin lesion healing time of all patients were also recorded.Results:The curative effect of patients in observation group was better than that of patients in control group (P＜0.05).After treatment,the levels of CD4,CD4/CD8 and NK cells of patients in both groups were significantly higher than those of patients before treatment (P＜0.05).After treatment,the CD4,CD4/CD8 and NK cells of patients in the observation group were significantly higher than those of patients in the control group (P＜0.05).After treatment,the levels of IL-4 of patients in both groups were significantly lower than those of patients before treatment,but IFN-γand IFN-γ/IL-4 were significantly higher (P ＜0.05).After treatment,the IL-4 of patients in observation group was significantly lower than that of patients in control group,IFN-γand IFN-γ/ IL-4 of patients in observation group were significantly higher than those of patients in control group (P＜0.05).When followed up 6 months after treatment,the recurrence rate and the skin lesion healing time of patients in the two groups were significantly lower than those of patients before treatment (P＜0.05).And the recurrence frequency and the skin lesion healing time of patients in observation group were significantly lower than those of patients in control group (P ＜ 0.05).Conclusion:Foscarnet sodium combined with acyclovir can significantly improve the immune function of patients with recurrent genital herpes.%目的:探讨膦甲酸钠联合阿昔洛韦对复发性生殖器疱疹患者免疫功能的影响.方法:将94例复发性生殖器疱疹患者分为观察组和对照组各47例.对照组采用阿昔洛韦治疗,观察组采用膦甲酸钠联合阿昔洛韦治疗.治疗前后,检测两组患者血清辅助T淋巴细胞(CD4)、细胞毒性T淋巴细胞(CD8)、CD4/CD8、自然杀伤细胞(NK细胞)、白介素4(IL-4)、干扰素γ(IFN-γ)、IFN-γ/ IL-4的水平.随访6个月,记录患者复发频率、皮损愈合时间的变化.结果:观察组疗效优于对照组(P＜0.05);两组治疗后CD4、CD4/CD8、NK细胞的水平均较治疗前升高,且观察组高于对照组(P＜0.05);两组治疗后IL-4水平较治疗前降低,IFN-γ、IFN-γ/ IL-4升高(P＜0.05),且观察组IL-4低于对照组,IFN-γ、IFN-γ/ IL-4高于对照组(P＜0.05);治疗后6个月随访,两组复发频率、皮损愈合时间较治疗前均明显降低,且观察组低于对照组(P＜0.05).结论:膦甲酸钠联合阿昔洛韦能提高复发性生殖器疱疹患者的疗效,并显著改善免疫功能.