血清β-HCG、孕酮水平在早期异位妊娠诊断中的应用

摘要

目的：探讨β-人绒毛膜促性腺激素（β-human chorionic gonadotropin ，β-HCG ）、孕酮（progesterone， P）对异位妊娠（ectopic pregnancy，EP）早期诊断的临床价值。方法回顾性分析2008～2012年柳州市第二妇幼保健院收治的50例EP患者（ A组）的临床资料，与同期50例宫内妊娠孕妇（ B组）相比较，观察两组间停经7周内与7周后的β-HCG、P水平的差异。通过ROC曲线分析确定EP的β-HCG、P临界值。结果停经7周内与7周后A组的β-HCG、P显著低于B组（ P＜0.05）。 ROC曲线分析显示，β-HCG、P的临界值分别为5321U/L、47 nmol/L时有较高的灵敏度和特异度。结论β-HCG与P对早期诊断EP有重要意义。%Objective To investigate the clinical value of beta human chorionic gonadotropin (β-HCG ) , progesterone ( P) in the early diagnosis of ectopic pregnancy .Methods A retrospective analysis of clinical data of 50 patients (group A) with the ectopic pregnancy during Jan .2008 to Dec.2012 in The second Maternal and Child Health Care Hospital of Liuzhou City were performed, compared with 50 cases of pregnancy (group B) over the same period.The β-HCG, progesterone levels of total cases in amenorrhea within 7 weeks and 7 weeks after were observed.And ROC curve was used in order to find the critical value of β-HCG, progesterone for diagnosis of ectopic pregnancy .Results Serum β-HCG of A group was significantly lower than B group ( P<0.05 ) .The ROC curve showed that critical value of β-HCG and progesterone were 5321U/L, 47nmol/L with higher sensitivity and specificity separately .Conclusion The serum β-HCG and progesterone have important significance in the early diagnosis of ectopic pregnancy .