目的探讨载药骨基质明胶（C-BMG）防治人工关节感染和松动的可能性。方法将C-BMG置入兔体内，于术后4h及1～15d每日采血，取骨组织和肌肉测定C-BMG体内释药浓度及持续时间。将C-BMG植入兔人工关节周围，术后4、6、8、10周不同时期测定兔人工关节周围的成骨情况。结果 C-BMG体内释药时，局部组织早期浓度高(>32.5μg/g)，以后为稳定的低浓度释放(<25μg/g)。C-BMG组人工关节周围成骨量及各时期股骨头拔出强度明显高于对照组(P<0.05)。结论 C-BMG既能持续释放抗生素防治人工关节感染，又能加速其生物学固定防治松动。%Objective To investigate the possibility of prevention and treatment of deep infection and aseptic loosening after joint replacement with cefazolin loaded bone matrix gelatin (C-BMG). Methods The C-BMG was implanted into the rabbits' body. The samples of blood, bone tissue and muscle were taken out 4 h, 1 to 5 days after operation to measure the concentrations of C-BMG in vivo and sustained duration duration of local tissues. C-BMG was implanted around rabbit prostheses in one group and other group without implantation of C-BMG served as control group. The tissues around prostheses were examined by several methods 4, 6, 8, 10 weeks postoperation. Results The drug concentrations of local tissues (bone and muscle) were higher in the early stage and kept resistant lower state later. The pull-out strength and osteoinductive quantity and quality of C-BMG group were greater than in the control group (P<0.05). Conclusion C-BMG can gradually release cefazolin for a prolong period to prevent and treat infection of artificial joint and accelerate periprostheses osteoinduction.
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