当前细菌对抗菌药物的耐药性已成为一个亟待解决的全球性公共卫生问题,而人体天然免疫的抗菌肽防御素具有不易产生耐药的优点,在感染性疾病中具有重要意义.目前国内外鲜有大量制备生物活性防御素的报道.人β-防御素3(HBD3)是防御素家族成员,具有广谱的抗菌活性,在多种感染性疾病中有抗炎作用.HBD3对耐药菌有杀伤作用,也是惟一抗菌活性不受盐浓度影响的防御素,对眼表感染尤为有利,是抗菌药新的候选者之一.就HBD3在眼表感染中的重要性及体外进行HBD3蛋白的合成和构效关系的优化予以综述,为HBD3及其他抗菌肽的工业化制备提供基础.%Currently,antimicrobial resistance has become an urgent global public health problem.Human defensin,a family of innate immune peptides,plays an important role in the control of infectious disease because of its low resistance to microbiological infection.However,so far there is seldom report on industrial production of bioactive defensin.Human β-defensin 3 (HBD3) is a member of human innate antimicrobial peptides.It has broad-spectrum antimicrobial activity and function in a variety of inflammation diseases.In addition,HBD3 is considered as a good candidate for antibiotics,because it has a strong killing activity to antibiotics-resistant microbes and resistance to highsalt environment,it is especially valuable for the treatment of ocular surface inflammatory diseases.This review covers the in vitro research on the production of HBD3,optimization of structure-activity and its antimicrobial potential for ocular surface infection,which may provide a supportive evidence for the commercial production of HBD3 and other antimicrobial peptides in biopharmaceutical area.
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