转化生长因子-β/Smads信号转导通路的泛素化调节在糖尿病视网膜病变中的作用

摘要

糖尿病视网膜病变(DR)是糖尿病常见和严重的并发症之一,参与的细胞因子和调节因子众多,其发病机制一直是DR防治研究的热点.研究证实,转化生长因子-β(TGF-β)参与了DR的发生和发展,Smads蛋白则能介导TGF-β/Smads信号通路的激活,进而参与DR的病理过程,而泛素-蛋白酶体途径(UPP)中的泛素连接酶Smurf则参与了TGF-β/Smads信号通路的降解调节.目前,相关研究已经取得了较大进展,就UPP对TGF-β/Smads信号转导通路的降解调节在DR中的作用进行综述.%Diabetic retinopathy (DR) is one of the common and serious diabetic complications,with a complex nosogenesis.Studies have shown that transforming growth factor-β (TGF-β) participates in the occurrence and development of DR,and Smads protein is able to mediate and activate TGF-β/Smads signal transduction pathway and further involves in the pathogenesis of DR.Smurf is one of the ubiquitin ligases in ubiquitin-proteasome pathway,and it is clarified to regulate TGF-β/Smads signal transduction pathway degradation.At present,the study on the relationship between TGF-β/Smads pathway and DR has made great progress.The role of ubiquitin-proteasome pathway regulating TGF-β/Smads signal transduction pathway in DR is reviewed in this article.