补体因子Ⅰ与年龄相关性黄斑变性发生研究进展

摘要

Age-related macular degeneration (AMD) is one of the most important diseases that cause vision loss among older patients in developed countries.As the progress of population aging in China,the incidence of AMD is increasing.The activation of the complement system plays an important role in AMD pathogenesis.Complement factor Ⅰ (CFI) is an important complement regulator.In recent years,there have been numerous studies about CFI single-nucleotide polymorphisms (SNPs) and AMD.The mechanism of CFI and the association between CFI polymorphisms and AMD were reviewed in the article.%年龄相关性黄斑变性(AMD)是引起发达国家老年人视力丧失的主要原因之一.随着中国人口老龄化的进展,AMD的发病率逐年升高,补体系统异常激活的炎症学说是目前研究较为深入的可能发病机制之一.补体因子Ⅰ(CFI)是补体系统中重要的抑制因子,抑制补体系统异常激活可能降低AMD的发生率.近来有大量关于CFI单核苷酸多态性(SNPs)与AMD发病相关性的研究,对CFI在AMD发病中的作用机制、CFI-SNPs与AMD发生的相关性研究最新进展进行总结.