巨噬细胞极化与AMD的关系

摘要

Age-related macular degeneration (AMD) is one of the leading causes to blindness worldwide in elderly population.Innate immune system elements, such as macrophages and cytokines, play an important role in AM D pathology and pathogenesis.In AMD,macrophages can be functionally polarized into M1 (classically activated) and M2 (alternatively activated), as well as regulatory cells, in response to systems biology approaches.Imbalances in the M1 and M2 populations together with activation of retinal microglia are observed and potentially contribute to tissue degeneration.In this review, the phenomenon of macrophage polarization in AMD study was summarized, and the relationship between macrophage polarization and dry AMD,wet AMD,AMD related risk factors were discussed.%年龄相关性黄斑变性(AMD)是世界范围内老年人群中主要的致盲原因之一.巨噬细胞在AMD的致病机制中有重要作用,随着病程的发展,巨噬细胞根据微环境的变化转化为经典活化的M1型或选择性活化的M2型.在AMD进程中,M1/M2失衡可能是造成黄斑变性的原因之一.本文就AMD研究中的巨噬细胞极化现象进行总结,分别探讨巨噬细胞极化与干性AMD、湿性AMD及AMD相关的危险因素之间的关系.