石家庄市体检人群Epstein-Barr病毒流行情况调查

摘要

目的 调查EBV在本地区体检人群中的流行情况.方法 应用酶联免疫吸附法检测EBV四种标志性抗体的阳性率并分析各项指标与临床诊断的关联性.结果 总共筛查198例EBV受检者,其中EBVCA-IgG阳性率最高,其次是EBNA-IgG和EBEA-IgG,阳性率最低为EBVCA-IgM,本地区未成年人感染EBV高于成年人,秋冬季高于其他季节,病例追踪发现EBVCA-IgG阳性和EBNA-IgG阳性与鼻咽癌密切相关.结论 EBV感染在人群中广泛存在,发生与地域、季节、年龄、自身免疫力有关,定期体检有助于相关疾病及早发现、早治疗.%Objective To investigate EBV prevalence in the local residents who took part in physical examination.Methods Four of EBV antibodies markers were detected by enzyme linked immunosorbent assay,and then the relationship between EBV serological markers and clinical outcome was further analyzed.Results There were 198 EBV antibodies tests in total,EBVCA-IgG positivity was the highest followed by EBNA-IgG and EBEA-IgG whereas the lowest positivity was found in EBVCA-IgM tests.Additionally,EBV prevalence was higher in adolescences than in adults,in autumn and winter than in other seasons.Case tracking suggested that EBVCA-IgG positivity and EBNA-IgG positivity were closely associated with nasopharyngeal carcinoma.Conclusion EBV infection was very common in general population and EBV transmission was affected by many factors such as region,season,age and host immunity.Routine physical examination was helpful for disease screen and control.