人乳头状瘤病毒混合感染对高度鳞状上皮内病变和宫颈癌的风险研究

摘要

Objective To study the effect of HPV coinfections on the risk of cervical cancer and precancerosis.Methods We randomly selected the female patients which did cervical pathology and not undergo any treatment in recent five years; PCR was used to detect HPV genotyping.Results A total of 755 patients (56.98％) were infected with HPV,154 in negative for intraepithelial lesion or malignancy (37.84％),152 in low-grade squamous intraepithelial lesion (47.64％),270 in high-grade squamous intraepithelial lesion (64.28％) and all of cervical cancer patients were infected (100％) ; HPV16 type is most common,followed by type 18,68 and 58.There were 423 patients with mixed infections,and HPV16 and HPV68 type mixed infections had a synergistic effect,can significantly improved the high-grade intraepithelial neoplasia and cervical cancer incidence.Conclusion HPV mixed infection is closely related to the cervical cancer,and HPV16 and HPV68 type mixed infections can significantly improved cervical cancer and precancerosis incidence.%目的 研究HPV混合感染对宫颈高度鳞状上皮内病变和宫颈癌发生的影响.方法 随机选取近五年在我院进行了宫颈病理学检查且没有经过任何治疗的女性患者,提取样本的DNA,PCR检测HPV的基因分型.结果 在收集的1325例患者中共有755例患者(56.98％)感染HPV,其中非宫颈癌或者癌前病变的患者中有154例(37.84％),低级别上皮内瘤样病变的患者中有152例(47.64％),高级别上皮内瘤样病变的患者中有270例(64.28％),宫颈癌患者全部感染(100％);在所有感染HPV的患者中,HPV16型最为常见,之后依次是18型,68型和58型;其中有423例患者为混合感染,约占总感染人数的56.03％,其中HPV16型和HPV68型混合感染具有协同作用,可以显著的提高高级别上皮内瘤样病变和宫颈癌发病率.结论 HPV的混合感染与宫颈癌的发生紧密相关,其中HPV16型和HPV68型可以显著的增加宫颈高级别上皮内瘤样病变和宫颈癌的发病风险.