METHOD OF PREDICTING VERSION OF DISEASE COURSE IN PATIENTS WITH LOW-GRADE SQUAMOUS INTRAEPITHELIAL LESIONS AT BACKGROUND OF PAPILLOMAVIRUS INFECTION

摘要

FIELD: medicine.;SUBSTANCE: method relates to field of medicine, namely to obstetrics and gynecology. In order to predict version of course of low-grade squamous intraepithelial lesion (LSIL) at the background of papillovirus infection Wald's sequential analysis is applied. Diagnostic coefficient DC is calculated for each sign by formula DC=101g*(P1/P2), where P1 is relative sign frequency in the first verifiable state, expressed in unity fractions; P2 is relative sign frequency in the second verifiable state. The following digns: viral load of human papilloma virus (HPV) of 16, 18 types; clinical-colposcopic index; immunohistochemical index pl6ink4a; age; beginning of sexual life; interval from menarche to sexual debut are taken into account. If DC sum is less than 13 bits, probability of favourable outcome of LSIL constitutes 95%, if DC is from plus 13 to plus 19 bits, probability of LSIL transition into high-grade squamous intraepithelial lesion (HSIL) constitutes 95%, if DC is higher than 20 bits, probability is 99%.;EFFECT: method makes it possible to predict version of course of low-grade squamous intraepithelial lesion at the background of papillovirus infection based on prognostic criteria of disease course.;2 ex, 1 tbl