孤立性心房颤动的相关危险因素分析

摘要

Objective To investigate the relative risk factors in patients with lone atrial fibrillation (LAF). Methods The patients with LAF treated with radiofrequency ablation (RFA) were chosen as LAF group (n=14), and patients with paroxysmal supraventricular tachycardia (PSVT) treated with RFA at the same time were chosen as control group (n=43) from Jan. 2011 to Jun. 2012. The general clinical data was collected from the patients in two groups, and the changes of age, blood pressure (BP), heart rate (HR), left atrial size, BMI, blood fat and plasma glucose were analyzed. Results Compared with control group, in LAF group left atrial size was largger [(35.93± 5.74) mm vs. (31.20±4.64) mm, P=0.007], levels of BMI (25.70±3.21 vs. 23.49±2.32, P=0.003), LDL-C [(2.85± 0.61) mmol/L vs. (2.23±0.31) mmol/L, P=0.038] and FBG [(5.96±1.64) mmol/L vs. (4.76±0.74) mmol/L, P=0.031] were higher, level of HDL-C [(1.14±0.21) mmol/L vs. (1.49±0.27) mmol/L, P=0.015] was lower, and TC and TG had no significant changes (P>0.05). The left atrial size was positively correlated to BMI (r=0.55, P<0.05), LDL-C(r=0.85, P<0.01) and FBG (r=0.81, P<0.01), and negatively correlated to HDL-C (r=-0.91, P<0.01). Conclusion LAF is not isolated in clinic, and left atrial size, BMI, blood fat and plasma glucose are its relative risk factors.%目的：探讨孤立性心房（LAF）颤动（房颤）患者的相关危险因素。方法纳入2011年1月～2012年6月间行射频消融术治疗孤立性房颤患者14例，将同期行射频消融术治疗单纯室上性心动过速（PSVT）的患者43例作为对照组。收集两组病例的一般临床资料，并对年龄、血压、心率、左房大小（LA）、体重指数（BMI）及血脂、血糖等生化指标进行分析。结果与对照组比较，LAF组患者左房较大[（35.93±5.74）mm vs.（31.20±4.64）mm，P=0.007]，体重指数（BMI；25.70±3.21 vs.23.49±2.32， P=0.003）、低密度脂蛋白胆固醇[LDL-C；（2.85±0.61）mmol/L vs.（2.23±0.31）mmol/L，P=0.038]及空腹血糖[Glu；（5.96±1.64）mmol/L vs.（(4.76±0.74）mmol/L，P=0.031]均较高，而高密度脂蛋白胆固醇较低[HDL-C；（1.14±0.21）mmol/L vs.（1.49±0.27）mmol/L，P=0.015]，总胆固醇及甘油三脂两组比较无明显差异（P＞0.05）。LA与BMI（r=0.55，P＜0.05）、LDL-C（r=0.85，P＜0.01）、Glu（r=0.81， P＜0.01）呈正相关，与HDL-C呈负相关（r=-0.91，P＜0.01）。结论 LAF在临床上并非孤立，LA、BMI、血糖、血脂均可能为孤立性房颤的相关危险因素。