Objective To systematically evaluated the correlation between SNP83 polymorphism in phosphodiesterase 4D (PDE4D) gene and ischemic stroke (IS) in Chinese Han population by meta-analysis. Methods The following databases such as PubMed, EMbase, CBM, CNKI, WanFang Data and VIP were searched to collect case-control studies about the relationship between PDE4D gene SNP83 polymorphism and IS in Chinese population. The retrieval time was from their establishment to January, 2017. Two researchers independently screened the literature according to the inclusion and exclusion criteria and extracted the data. The quality of the literature was assessed according to the NOS. Then the meta-analysis was performed by Stata 12.0 software. Results A total of 14 case-control studies which are 9 in Chinese and 5 in English involving 4119 IS patients and 4286 controls. The results of meta-analysis showed that, for Chinese Han population, no significant association was observed in all five genetic models (C vs. T: OR=1.13, 95%CI: 0.95~1.33, P=0.17; CC vs. TT: OR=1.12, 95%CI: 0.80~1.57, P=0.52; CT vs. TT:OR=1.22, 95%CI: 0.91~1.63, P=0.23; CC vs. CT+TT: OR=1.10, 95%CI: 0.81~1.49, P=0.56; CC+CT vs. TT: OR=1.14, 95%CI: 0.93~1.41, P=0.21). Conclusion Current evidence showed that PDE4D gene SNP83 polymorphism may not be significantly associated with an increased risk of IS in Chinese Han population.%目的 通过Meta分析的方法综合评价磷酸二酯酶4D(PDE4D)基因SNP83多态性与中国人群缺血性脑卒中(IS)的相关性.方法 计算机检索PubMed、EMbase、CNKI、CBM、Wanfang Data和VIP,搜集关于探讨PDE4D基因SNP83多态性与中国人群IS相关性的病例-对照研究,检索时限均为建库至2017年1月.由两人独立对符合纳入标准的研究进行数据提取,并对纳入研究按照NOS量表进行质量评价,然后采用Stata 12.0软件进行Meta分析.结果 共纳入14项病例-对照研究,中文文献9篇,英文文献5篇,包括4119例IS和4286例对照.总体Meta分析结果显示,对于中国汉族人群,PDE4D基因SNP83多态性与IS发病风险无相关性(C vs. T:OR=1.13,95%CI:0.95~1.33,P=0.17;CC vs. TT:OR=1.12, 95%CI:0.80~1.57,P=0.52;CT vs. TT:OR=1.22,95%CI:0.91~1.63,P=0.23;CC vs. CT+TT:OR=1.10,95%CI:0.81~1.49,P=0.56;CC+CT vs. TT:OR=1.14,95%CI:0.93~1.41,P=0.21).结论当前研究证据显示,PDE4D基因SNP83多态性与中国汉族人群IS发病风险无相关性.由于纳入研究数量的限制,该结论尚需进一步开展相关研究进行验证.
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