红细胞分布宽度、血小板分布宽度、高敏C反应蛋白水平与房颤的关系

摘要

Objective To investigate the changes of High-sensitivity C-reactive protein (hs-CRP), Red blood cell distribution width (RDW) and Platelet distribution width (PDW) in patients with atrial fibrillation (AF) and their relationships with atrial fibrillation. Method A total of 60 AF patients were selected as AF group and 60 inpatients with sinus rhythm were selected as control group from Dec. 2015 to Sep. 2016. RDW, PDW were measured using automatic blood cell analyzer, hs-CRP was measured by ELISA, left atrium diameter (LAD), left interior diameter (LVD), interventricular septum (IVS), left ventricular posterior wall thickness (LVPW), left ventricular ejection fraction (LVEF) were measured by doppler echocardiography. There was no significant difference in sex ratio, age, the proportion of combined disease, red blood cell count and hemoglobin between the two groups (all P>0.05). The RDW, PDW, hs-CRP and LAD in atrial fibrillation group were significantly higher than those in control group (all P<0.05). Result of multivariate Logistic regression analysis showed that there were significant differences in the incidence of RDAD (OR=1.070, 95%CI: 1.015~1.121), PDW (OR=1.050, 95%CI: 1.019~1.082), LAD(OR=1.064, 95%CI: 1.021~1.098) is an independent risk factor for atrial fibrillation. Conclusion hs-CRP, RDW and PDW are elevated in patients with AF, and are risk factors for the onset of atrial fibrillation.%目的 探讨心房颤动(房颤)患者高敏C反应蛋白(hs-CRP)、红细胞分布宽度(RDW)和血小板分布宽度(PDW)的变化,以及其与房颤的关系.方法 选择2015年12月~2016年9月于合肥市第三人民医院心内科住院的房颤患者60例纳入房颤组,男性34例,女性26例,年龄44~82(67.2±12.1)岁;同期住院的窦性心律患者60例纳入对照组,其中男性35例,女性25例,年龄45~82(65.2±10.2)岁.采用全自动血细胞分析仪检测RDW、PDW,ELISA测定hs-CRP,心脏超声测定左房内径(LAD)、左室内径(LVD)、室间隔厚度(IVS)、左室后壁厚度(LVPW)、左室射血分数(LVEF).结果 两组性别比、年龄、合并疾病比例和红细胞计数、血红蛋白等比较,差异均无统计学意义(P均>0.05).房颤组RDW、PDW、hs-CRP以及LAD均高于对照组,差异有统计学意义(P均<0.05).多因素Logistic回归分析结果发现,RDW(OR=1.070,95%CI:1.015~1.121)、PDW(OR=1.050,95%CI:1.019~1.082)、LAD(OR=1.064,95%CI:1.021~1.098)是房颤的独立危险因素.结论 hs-CRP、RDW和PDW在房颤患者中均升高,且为房颤发病的危险因素.