浙江省2005-2010年结直肠癌生存率分析

摘要

Objective To analyze the survival rate of colorectal cancer,using data from the population-based cancer registry during 2005-2010 in Zhejiang.Methods The last follow-up activites on 17 235 cases regarding the survival status was December 31,2012.Both cumulative observed survival rate (OS) and relative survival rate (RS) were calculated with SURV 3.01 software drawn up by Hakulinen.Results The OS on 1,3 and 5 year were 76.71％,58.14％,50.58％ and the RS on 1,3 and 5 year were 78.93％,63.48％,58.73％,respectively.The 1,3 and 5 year relative survival rates on males vs.females were 79.36％ vs.78.35％,63.63％ vs.63.29％,and 58.85％ vs.58.57％,respectively and the difference between them was not statistically significant (x2=1.08,P=0.298).The 5 year OS and RS of the urban population were 55.06％ and 64.09％ and the 5 year OS and RS of the rural population were 47.59％ and 55.16％,with statistically significant differences (x2 =85.84,P＜0.001).The 55-64 age group appeared higher relative survival rate.There were significant differences in the survival rates among different age groups (x2=333.42,P＜0.001).The 5 year RS of colon vs.rectum were 61.47％ vs.56.45％.Colon patients showed better relative survival rate (x2=7.26,P＜0.05).Conclusion The wide variations in colorectal cancer survival rates were seen between the urban and rural populations.Public health resources should be focused on rural areas.Patients younger than 55 years should be under specific attention to further understand the related factors which influencing the prognosis of the diseases.%目的 分析2005-2010年浙江省30个卫生监测区全人群结直肠癌患者的生存率.方法 随访浙江省卫生监测区2005-2010年17 235例结直肠癌患者的生存情况,生存时间计算截至2012年12月31日,利用SURV 3.01软件计算观察生存率(OS)及相对生存率(RS).结果 结直肠癌患者1、3、5年OS分别为76.71％、58.14％、50.58％,RS为78.93％、63.48％、58.73％.其中男性RS为79.36％、63.63％、58.85％;女性RS为78.35％、63.29％、58.57％,男女性生存率差异无统计学意义(x2=1.08,P=0.298).城市地区5年OS和RS分别为55.06％与64.09％,高于农村地区的47.59％和55.16％,差异有统计学意义(x2=85.84,P＜0.001).55 ～ 64岁组5年RS为66.02％,高于其他年龄组,各年龄组间生存率差异有统计学意义(x2=333.42,P＜0.001).结肠癌与直肠癌5年RS分别为61.47％和56.45％,结肠癌患者中长期RS高于直肠癌患者(x2=7.26,P＜0.05).结论 浙江省结直肠癌生存率存在地区差异,公共卫生资源应向农村地区倾斜;影响＜55岁结直肠癌患者生存率的因素有待进一步研究.