长期应用阿托伐他汀对新发2型糖尿病患者血脂及动脉中层厚度的影响

摘要

目的：观察阿托伐他汀对新发2型糖尿病患者血脂及动脉中层厚度（IMT）的影响。方法使用中国糖尿病并发症防治研究（CDCPS）数据，分析333例新发2型糖尿病患者使用阿托伐他汀24个月前后的血脂水平及颈动脉、股动脉和髂动脉IMT的变化。数据分析采用χ2检验、单因素方差分析、协方差分析和配对t检验。结果新发2型糖尿病患者用药后TC、TG及LDL-C水平显著下降（P值均为0.000），且均保持在较低水平；用药24个月后股动脉IMT较基线水平显著下降（P＝0.022），颈动脉和髂动脉IMT并无显著变化；研究期间未观察到阿托伐他汀的严重不良反应。结论长期应用阿托伐他汀能安全有效降低2型糖尿病患者血脂水平，并能延缓动脉粥样硬化的发展。%Objective To analyze the impact of atorvastatin on blood lipids and arterial media thickness(IMT)in new-onset type 2 diabetes patients. Methods 333 patients,30-70 years old and diagnosed within one year as type 2 diabetes,were selected from the Chinese Diabetes Complication Prevention Study(CDCPS)to take part in this study. Changes of blood lipids and IMT of carotid, femoral and iliac artery pre and post the administration of atorvastatin were tested and followed for 24 months. Results Total cholesterol,triglycerides and low-density lipoprotein decreased significantly (P=0.000)and maintained at a low level. The carotid artery IMT decreased significantly(P=0.022) at the end of this study,but the femoral and iliac artery IMT did not show any obvious change. There were no serious adverse events noticed,during the study period. Conclusion Long-term use of atorvastatin seemed to be safe and effective in reducing blood lipids in patients with type 2 diabetes thus could delay the development of atherosclerosis.