3,3′-二(四唑-5-基)二呋咱基醚的合成与表征

摘要

以3-氨基-4-氰基呋咱为起始原料,经氧化、醚化、环化三步反应合成了未见文献报道的化合物3,3′-二(四唑-5-基)二呋咱基醚,总收率46.7％,经13C NMR、IR、MS、元素分析确认了其结构.确定了环化反应适宜的反应条件:反应时间4h,ZnCl2·2H2O为催化剂,n(ZnCl2·2H2O)∶n(FOF-2) =1∶1,并对锌盐催化的四唑环合成机理进行了探讨.%3 ,3'-Bis( tetrazol-5-yl) difurazanyl ether was designed and synthesized with a yield of 46.7% from 3-amino-4-cyano furazan through oxidation,ertherification and cyclization,and was characterized by 13C NMR,IR,MS and elemental analysis. In addition,the mechanism of cyclization promoted by Zn2+ was proposed and discussed,and the reaction conditions of cyclization were optimized as follows: time is 4 h,ZnCI2 ? 2H2O as catlyst.molar ratio of ZnCI2 ? 2H2O to FOF-2 is 1 : 1.