ENDOTHELIN ANTAGONISTS: N-2'- (4,5-DIMETHYL-3-ISOXAZOLYL) AMINOSULFONYL-4-(2-OXAZOLYL) 1,1'-BIPHENYL-2-YLMETHYL -N,3,3-TRIMETHYLBUTANAMIDE AND N-(4,5-DIMETHYL-3-ISOXAZOLYL) -2'-(3,3-DIMETHYL-2-OXO-1-PYRROLIDINYL) METHYL -4'-(2-OXAZOLYL)1,1'-BIPHENYL-2-SULFONAMIDE AND SALTS THEREOF

摘要

The compounds N-[[2'-[ [(4,5-dimethyl-3-isoxazolyl) amino]sulfonyl]-4-(2-oxazolyl) [1,1'-biphenyl]-2-yl]methyl]-N, 3,3-trimethylbutanamide and N-(4,5-dimethyl-3-isoxazolyl)-2'-[ (3,3-dimethyl-2-oxo-1-pyrrolidinyl) methyl]-4'-(2-oxazolyl) [1,1'-biphenyl]-2-sulfonamide, and salts thereof, useful asendothelin antagonists.