氟对大鼠脂质过氧化和抗氧化能力的影响

摘要

目的　探讨氟对大鼠血和各组 织丙二醛（MDA）水平、超氧化物歧化酶（SOD）活力及全血谷胱甘肽过氧化物酶（GS H-Px）活力的影响。方法　运用动物实验，采用饮水加氟的方法。结果　染氟可使大鼠血清、肝脏、肾脏、脑中MDA含量 显著增加；全血和肝脏、肾脏、心脏、睾丸的SOD活性显著降低；全血GSH-Px活性降低 。结论　氟可促进机体脂质过氧化，抑制抗氧化酶（SOD ，GSH-Px）的活力。%Objective　To study the effects of fluoride on contents of MDA and the activities of SOD and GSH-Px in organism.Methods　By means of subchronic animal experiment.Results　In the fluoride-treated group:The contents of MDA in serum,liver,kidney and brain of rat increased significantly.The activitie s of SOD in blood,liver,kidney,heart and testis decreased significantly.The acti vities of GSH-Px in blood decreased strikingly.Conclusions　The results showed that fluoride could induce lipid peroxidation and decrease the capacity of antioxidaase(SOD,GSH-Px).