利奈唑胺群体药代/药效动力学研究进展

摘要

Linezolid, a new drug of oxazolidinone, has satisfying clinical efficacy and safety on community-acquired or hospital-acquired infection resulting from gram-positive cocci. We reviewed the priority of nonlinear mixed-effects modeling for analysis of population pharmacokinetics/ pharmacodynamics, and the present advances of population pharmacokinetics/ pharmacodynamics on linezolid research.%利奈唑胺属于新型(口恶)唑烷酮类药物,对于耐药革兰阳性球菌引起的社区、院内感染均有良好的临床疗效和安全性.本文综述了非线性混合效应模型法在群体药代/药效动力学研究中的作用及其在利奈唑胺研究的应用进展.