Objective: To explore the correlation among the serum concentrations of HIF-1α, VEGF-A, CEA, CA19-9, the patients' clinicopathological features, recurrence or metastasis in gastric cancer patients after curative resection. Methods: Using retrospective method, a total of 76 cases of gastric cancer patients after radical surgery from January 2010 to September 2012 in our department were extracted. The serum concentrations of HIF-1α, VEGF-A, CEA and CA19-9 were analyzed before and after adjuvant chemotherapy, at the last visit before follow-up deadline/the occurrence of recurrence or metastasis. Results: There were no signiifcant differences in the concentrations of HIF-1α, VEGF-A, CEA and CA19-9 before and after adjuvant chemotherapy in 76 patients (P>0.05). The concentrations of HIF-1αand CEA of 35 gastric cancer patients increased signiifcantly after recurrence or metastasis compared with those before adjuvant chemotherapy (P0.05）。35例复发转移患者复发转移时血清HIF-1α、CEA浓度较辅助化疗前升高，差异有统计学意义（P <0.05）。35例患者复发转移时血清HIF-1α、CEA浓度较41例未复发转移患者随访截止前最近一次复诊时升高，差异有统计学意义（P<0.05）。亚组分析示31例血清CEA浓度维持在正常水平的患者，12例复发转移患者的血清HIF-1α浓度较19例未复发转移患者明显升高（P=0.022）。结论：胃癌根治术后患者复发转移时血清HIF-1α、CEA浓度升高；CEA浓度在正常范围内的患者，复发转移时血清HIF-1α浓度升高，提示根治术后患者血清HIF-1α浓度的动态升高可能预示胃癌复发转移。
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