Objective To summarize the experience of surgical management of postoperative intrahepatic duct stones and strictures with choledochoscope.Methods The clinical data of 1241 patients with intrahepatic duct stones and strictures who were admitted to the Shenzhen People's Hospital from January 2000 to December 2011 were retrospectively analyzed.All patients were divided into postoperative choledochoscopy group (652 patients were treated by choledochoscope through T-tube fistula) and conservative treatment group (589 patients were treated by cholangic and antibiotic drugs) according to treatment plan.The clinical data including stricture alleviation,incidence of complications and treatment efficacies of the 2 groups were compared using the chi-square test.Results In the postoperative choledochoscopy group,the intrahepatic duct stones of 630 patients were completely removed,with the removal rate of 96.63％ (630/652),which was significandy higher than 76.23％ (449/589) of the conservative treatment group (x2=113.407,P ＜ 0.05).A total of 1237 intrahepatic duct strictures were detected in the postoperative choledochoscopy group,including 698 cases of membranous stricture (the length of strictured bile duct ＜ 2 mm),529 cases of spool-shaped stricture (2 mm ≤ the length of strictured bile duct ≤5 mm),8 cases of long tube-shaped stricture (the length of strictured bile duct ＞ 5 mm),2 cases of crackshaped stricture.The alleviation rate of the stricture was 99.35％ (1229/1237).The conditions of 6 cases of long tube-shaped stricture and 2 cases of crack-shaped stricture were not alleviated.There were 986 cases of intrahepatic duct strictures in the conservative treatment group,and the stricture alleviation rate was 80.43％ (793/986).There was a significant difference in the stricture alleviation rate between the 2 groups (x2=238.994,P ＜ 0.05).Nine patients in the postoperative choledochoscopy group had severe complications.Five patients had intrahepatic duct hemorrhage with a volume of blood loss more than 1500 ml,and they were treated by balloon dilatation hemostasis.One patient with repeated intrahepatic duct bleeding received hepatectomy.Two patients with severe intrahepatic cholangitis received choledochoscopy.Two patients had incomplete formation of sinus and they received implantation of biliary stents under duodenoscope.Conclusion Standard surgical management with choledochoscope can effectively alleviate postoperative intrahepatic duct stones and strictures.%目的 探讨胆道镜治疗肝切除术后肝内胆管结石合并胆管狭窄的疗效.方法 回顾性分析2000年1月至2011年12月暨南大学第二临床医学院深圳市人民医院收治的1241例肝内胆管结石合并胆管狭窄患者的临床资料.根据患者肝切除术后治疗方案分为术后胆道镜组(652例患者,应用胆道镜经T管窦道取石)和保守治疗组(589例患者,门诊随访有症状时给予利胆和抗生素类药物治疗).分析两组患者的结石治疗效果、狭窄解除效果和并发症治疗效果,两组间计数资料比较采用,检验.结果 术后胆道镜组患者结石清除率为96.63％(630/652),高于保守治疗组患者的76.23％(449/589),两组比较,差异有统计学意义(x2=113.407,P＜0.05).术后胆道镜组患者共发现胆管狭窄1237支,其中膜状狭窄(狭窄段＜2 mm)698支、短管状狭窄(2 mm≤狭窄段≤5 mm)529支、长管状狭窄(狭窄段＞5 mm)8支、“门缝样”狭窄(其内大量结石)2支；狭窄解除率为99.35％(1229/1237),6支长管状狭窄和2支“门缝样”狭窄未能解除.保守治疗组患者共发现胆管狭窄986支,狭窄解除率为80.43％(793/986),两组比较,差异有统计学意义(x2=238.994,P＜0.05).术后胆道镜组中9例患者发生严重并发症.5例胆道大出血患者(碎石电极击穿胆管壁3例、球囊扩张2例)出血量均＞ 1500 ml,通过球囊压迫止血,其中1例反复出血3次,在第3次出血停止后行出血胆管所在肝叶切除术而治愈.肝内重症胆管炎2例,经过急诊胆道镜治疗,解除胆管梗阻而治愈.窦道形成不全2例,均为80岁以上患者,经十二指肠镜放置胆管塑料支架管后治愈,但肝内胆管结石未能取出.结论 肝切除术后规范的胆道镜治疗能有效解除肝内胆管狭窄,取尽结石.
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