西沙必利对慢性功能性便秘患者结肠转运时间的作用

摘要

Objective To investigate colonic transit time (CTT) in normal subjects and evaluate the effect of cisapride on CTT on chronic functional constipation. Methods Total and segmental CTT were mea-sured in 25 healthy volunteers and 25 patients with chronic functional constipation using radiopaque markers ingested on each of 3 consecutive days with abdominal X-rays obtained on the 4th and 7th days. Patients with prolonged total CTT received cisapride 10 mg t. i.d. orally for 4 weeks and CTT was measured again in the last week. Results The maximum normal value of total CTT was 56 h, it was prolonged in 15 of 25 consti-pated patients. On average the total CTT was significantly shortened from 103.07 h to 66.80 h ( P < 0.01 ),the segmental CTT were also shortened significantly. Conclusion The technique to measure CTT is simple,convenient and reliable. Cisapride, which can reduce total and segmental CTT, is an effective drug in chronic functional constipation.%目的了解国人结肠转运时间的正常值，并探讨西沙必利对慢性功能性便秘患者的结肠转运时间(CTT)的作用。方法通过连续3 d各服一粒含不透X线标志物的胶囊后于第4、第7天拍摄腹部平片的简化方法，测定25例正常人及25例慢性功能性便秘患者的全结肠及节段结肠转运时间。对全结肠转运时间延长的便秘患者，给予西沙必利10 mg每日3次口服治疗，疗程4周。在最后1周复查CTT，比较服药前后CTT的变化。结果全结肠转运时间的正常值上限为56 h，25例便秘患者中15例的全结肠转运时间延长，经西沙必利治疗后平均全结肠转运时间由103．07 h缩短至66．80 h(P<0．01)，各节段结肠转运时间亦显著缩短。结论简化的CTT检查技术简单易行，结果可靠。西沙必利能显著缩短慢性功能性便秘患者的全结肠及各节段结肠转运时间，可常规用于慢性功能性便秘患者。