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A Phase 1B, Double-blind, Placebo-controlled, Parallel-group, Multi-dose Study of the Pharmacodynamics of NGM282 on Colonic Transit, Bile Acid Homeostasis and Fecal Fat in Subjects with Functional Constipation

机译：1B，双盲，安慰剂控制，并行组，NGM282对结肠转运，胆汁酸痛和患者功能性便秘的粪便脂肪的药物动力学的多剂量研究

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作者
Oduyebo, Ibironke.;
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作者单位

College of Medicine - Mayo Clinic.;

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授予单位 College of Medicine - Mayo Clinic.;
学科
学位 M.S.
年度 2018
页码 63 p.
总页数 63
原文格式 PDF
正文语种 eng
中图分类 AAI10747421;
关键词
Bile acid; C4; FGF19; FGFR4; Klothoβ; Prokinetic;

机译：胆汁酸;C4;FGF19;FGFR4;Klothoβ;动力学;
入库时间 2022-08-17 12:00:47

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专利

1. Effects of NGM282, an FGF19 variant, on colonic transit and bowel function in functional constipation: a randomized phase 2 trial [J] . Oduyebo Ibironke, Camilleri Michael, Nelson Alfred D., The American Journal of Gastroenterology . 2018,第5期

机译：NGM282，FGF19变体，结肠交通和肠功能在功能便秘中的影响：随机阶段2试验
2. Analysis of Fecal Primary Bile Acids Detects Increased Stool Weight and Colonic Transit in Patients With Chronic Functional Diarrhea [J] . Vijayvargiya Priya, Camilleri Michael, Chedid Victor, Clinical gastroenterology and hepatology: the official clinical practice journal of the American Gastroenterological Association . 2019,第5期

机译：粪便原发性胆汁酸的分析检测慢性函数腹泻患者的大便重量和结肠交通量增加
3. A phase II, randomized, placebo-controlled, double-blind, multi-dose study of SRT2104, a SIRT1 activator, in subjects with type 2 diabetes [J] . BaksiA., KraydashenkoO., ZalevkayaA., British Journal of Clinical Pharmacology . 2014,第1期

机译：II期随机，安慰剂对照，双盲，多剂量SRT2104（SIRT1激活剂）对2型糖尿病患者的研究
4. Effects of 28-day Bifidobacterium animalis subsp. lactis HN019 supplementation on colonic transit time and gastrointestinal symptoms in adults with functional constipation: A double-blind randomized placebo-controlled and dose-ranging trial [O] . Alvin Ibarra, Mathilde Latreille-Barbier, Yves Donazzolo, 2018

机译：28天动物双歧杆菌亚种的影响。乳酸HN019补充剂对成人功能性便秘患者结肠传输时间和胃肠道症状的影响：一项双盲随机安慰剂对照和剂量范围试验
5. Sa2051 A Phase II, Randomized, Double-Blind, Placebo-Controlled, Multiple-Dose, Parallel-Group Study to Evaluate the Efficacy, Safety, and Pharmacodynamics of RM-131 in Patients With Chronic Constipation [O] . Andres Acosta, Gururaj Kolar, Johanna Iturrino, 2014

机译：SA2051 A期，随机，双盲，安慰剂控制，多剂量，并行组研究，以评估慢性便秘患者RM-131的疗效，安全性和药效学

A Phase 1B, Double-blind, Placebo-controlled, Parallel-group, Multi-dose Study of the Pharmacodynamics of NGM282 on Colonic Transit, Bile Acid Homeostasis and Fecal Fat in Subjects with Functional Constipation

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