BCSG1、c-erbB-2、VEGF表达与乳腺癌临床病理因素相关性研究

摘要

Objective To evaluate the expression of BCSG1, c-erbB-2, VEGF in human breast carcinoma and the relationship with clinical-pathological features. Methods By immunohistochemical S-P method, the expressions of BCSG1, c-erbB-2 and VEGF were examined in 316 breast cancer specimens, the correlation between these indexes and clinical-pathologi cal features were analyzed. Results BCSG1 and VEGF positive rate were 67. 1% and 61. 0% . The expression of BCSG1 and VEGF were both positively correlated with histological grade, lymph node metastasis and clinical stage( r = 0. 152, r = 0.510, r =0.460 andr =0. 166, r =0. 142, r =0. 142, P <0. 05, P < 0. 01 ), and both independence with ER, PR, tumor size, menstruation, pathology type( P > 0. 05 ). C-erbB-2 positive rate was 32. 2% , the expression of c-erbB-2 was positively correlated with tumor size, histological grade, lymph node metastasis and clinical stages ( r =0. 173, r =0. 157, r = 0.365, r =0.306, P <0.01 ), but negatively correlated with ER, PR expressions ( r = -0. 149, r = -0. 154, P < 0.05 ), and independence with menstruation and pathology type ( P >0. 05 ). The co-expression of these three proteins positively correlated with lymph node metastasis, clinical stages and histological grade,( r =0.457, r =0.377, r =0.228, P < 0.05 ). The expression of BCSG1, c-erbB-2 and VEGF were all positively correlated with each other( P <0. 01 ). Conclusion The expression of BCSG1, c erbB 2 and VEGF were correlated with carcinogenesis of breast cancer nd development. The high co-expression of the three proteins predicts strong aggression and metastasis ability.%目的 研究乳腺癌组织中乳腺癌特异基因1(BCSG1)、人表皮生长因子受体-2(c-erbB-2)、血管内皮生长因子(VEGF)分别及联合表达情况与临床病理学特征的关系.方法 随机抽取316份临床病理资料完整的乳腺癌标本,采用免疫组化S-P法检测BCSG1、c-erbB-2、VEGF的表达情况,并结合临床病理特征进行分析.结果 乳腺癌组织BCSG1、VEGF阳性表达率分别为67.1%、61.0%,均与组织学分级、淋巴结转移、临床分期呈正相关(分别为r=0.152、r=0.510、r=0.460及r=0.166、r=0.142、r=0.142,P<0.05,P<0.01),与ER、PR、肿瘤大小、月经状况、病理类型无关(P>0.05);c-erbB-2阳性表达率32.2%,与肿瘤大小、组织学分级、淋巴结转移、临床分期呈正相关(r=0.173、r=0.157、r=0.365、r=0.306,P<0.01);与ER、PR呈负相关(r=-0.149,r=-0.154,P<0.05),与月经状况、病理类型无关(P>0.05); BCSG1、c-erbB-2、VEGF共同表达与淋巴结转移、临床分期、组织学分级呈正相关(r=0.457、r=0.377、r=0.228,P<0.05);BCSG1、c-erbB-2、VEGF之间两两表达呈正相关(P<0.01).结论 BCSG1、c-erbB-2、VEGF的表达与乳腺癌发生、发展及侵袭转移有关,三者同时高表达提示肿瘤具有更高的侵袭转移能力.