急性心肌梗死患者生长分化因子-15、心肌梗死标志物水平表达及其相关性研究

摘要

Objective To investigate the relationship between acute myocardial infarction ( AMI ) patients serum growth differentiation factor-15 (GDF-15), the myocardial infarction three [isoenzyme of creatine kinase (CK-MB), troponin I (cTnI), myoglobin (Mb)] expression.Methods 116 cases of AMI patients as AMI group, they were divided into 2 sub-groups, the ST segment elevation myocardial infarction (STEMI group) with 58 cases, non ST segment elevation myocardial infarction (NSTEMI) group with 58 cases, using enzyme-linked immunosorbent assay (ELISA method) to determine the ser-um GDF-15 level, CK-MB, cTnI, Mb levels were determined using fluorescence immunoassay method;and 106 healthy sub-jects as healthy controls were compared .Results AMI group's GDF-15, CK-MB, cTnI, Mb levels were increased than health-y control group significantly ( P <0.01), where STEMI sub group were increased obviously than in NSTEMI group ( P <0.05).Correlation analysis showed that GDF-15 and CK-MB, cTnI, Mb were positively correlated ( r =0.558, r =0.579, r =0.545, P <0.01).Conclusion In the pathogenesis of AMI, blood GDF-15, CK-MB, cTnI, Mb, and STEMI were in-creased obviously .GDF-15 and CK-MB, cTnI, Mb were positively correlated , the combined detection of these indexes is helpful for early diagnosis and risk stratification of AMI .%目的：研究急性心肌梗死（AMI）患者血浆生长分化因子-15（GDF-15）、心肌梗死三项[肌酸激酶同工酶（CK-MB）、肌钙蛋白I（cTnI）、肌红蛋白（Mb）]表达水平及其之间的关系。方法以116例AMI患者作为AMI组，分为2个亚组，其中ST段抬高型心肌梗死（ STEMI亚组）58例，非ST段抬高型心肌梗死（ NSTEMI亚组）58例，采用酶联免疫吸附试验（ ELISA法）测定血GDF-15水平，采用荧光免疫定量法测定CK-MB、cTnI、Mb水平；并以106例健康查体者作为健康对照组进行比较。结果 AMI组血GDF-15、CK-MB、cTnI、Mb水平较健康对照组均显著增高（ P ＜0构．01），其中STEMI亚组较NSTEMI亚组升高更明显（ P ＜0．05）。相关分析显示GDF-15与CK-MB、cTnI、Mb均呈正相关（ r ＝0．558、r ＝0．579、r ＝0．545， P ＜0．01）。结论在AMI发病过程中，血GDF-15、CK-MB、cTnI、Mb水平升高，且STEMI患者升高更明显。 GDF-15与CK-MB、cTnI、Mb呈正相关，联合检测可能更有助于AMI的早期诊断和危险分层。