急性缺血性脑卒中患者血清淀粉样蛋白A及胱抑素C水平与病情程度相关性研究

摘要

Objective To observe acute ischemic stroke patients serum amyloid A (SAA) and cystatin C (CysC) levels, to explore the relationship between the pathogenesis of acute ischemic stroke and SAA , CysC.Methods Collected pa-tients with acute ischemic stroke in 66 cases as the observation group;20 cases of healthy people as healthy control group .The 2 groups were collected venous blood , using the method of ELISA for determination of serum SAA , CysC levels .The observa-tion group in the hospital within 24 h were underwent National Institute of Health Stroke Scale ( NIHSS) score evaluation , and the correlation between SAA , CysC level and NIHSS score were analyzed .Results Observation group's serum level of SAA [(2.293 ±1.067) mg/L vs.(0.405 ±0.189) mg/L],CysC [(1.924 ±0.693) mg/L vs.(0.681 ±0.173) mg/L] was significantly higher than the control group ( t =13.679, t =13.271, P <0.05).The observation group according to NIHSS score were divided into light sub-group with 17 cases (<4 points), and medium subgroup of 45 cases (4~15 points), se-vere subgroup with 4 cases (>15 points);3 subgroups'SAA, CysC levels showed significant differences ( P <0.05), re-spectively, as severe subgroup >medium subgroup >light subgroup.Observation group's serum SAA, CysC levels were pos-itively correlated with NIHSS score ( r =0.981, r =0.934, P <0.05).Conclusion Acute ischemic cerebral stroke patients whose serum SAA , CysC levels were significantly higher than those of healthy people , the serum SAA and CysC level were positively correlated with NIHSS score .%目的：观察急性缺血性脑卒中患者血清淀粉样蛋白A（SAA）及胱抑素C（CysC）水平变化，探讨急性缺血性脑卒中的发病机制及与SAA、CysC的关系。方法收集急性缺血性脑卒中患者66例作为观察组；健康体检者20例为健康对照组。2组均采集空腹肘静脉血，采用ELISA 法测定血清SAA 、CysC水平。观察组于入院24 h内进行美国国立卫生院卒中量表（ NIHSS）评分，并对SAA、CysC水平与NIHSS评分的相关性进行分析。结果观察组血清SAA水平[（2煙．293±1．067）mg/L vs．（0．405±0．189）mg/L]、CysC水平[（1．924±0．693）mg/L vs．（0．681±0．173） mg/L]明显高于对照组（ t ＝13．679、t ＝13．271， P均＜0．05）。观察组按NIHSS评分分为轻型亚组17例（＜4分），中型亚组45例（4～15分），重型亚组4例（＞15分）；3个亚组间比较，SAA、CysC 水平差异均有统计学意义（ P ＜0．05），分别为重型亚组＞中型亚组＞轻型亚组。观察组血清SAA、CysC水平与NIHSS评分之间均呈正相关（ r ＝0．981、r ＝0．934， P均＜0．05）。结论急性缺血性脑卒中患者血清SAA、CysC水平明显高于正常健康人，血清SAA、CysC水平与NIHSS评分均呈正相关性。