Objective To investigate the relationship between STOP-Bang questionnaire and cognitive function in pa-tients with moderate to severe obstructive sleep apnea hypopnea syndrome (OSAHS), and to evaluate its clinical application value.Methods Ninety-four patients with severe OSAHS were confirmed by polysomnogram were enrolled , according to the STOP-Bang questionnaire, they were divided into severe group (44 cases) and moderate group (50 cases), and mini mental status scale ( MMSE) were used to assess cognitive function in patients , the relationship between STOP-Bang questionnaire re-sults and cognitive function were analyzed by Pearson correlation analysis and ROC curve .Results Comparing with the pa-tients of moderate group, patients in severe group with a higher proportion of hypertension (59.1%vs.36.0%, P =0.03), body mass index [(30.3 ±2.5) kg/m2 vs.(28.5 ±1.7) kg/m2],apnea hypopnea index [(51.2 ±2.4) /h vs.(26.5 ± 3.5) /h] and STOP-Bang total scores (5.6 ±1.2 vs.2.3 ±0.6), while the low oxygen saturation [(62.7 ±4.6)% vs. (78.2 ±3.8)%], rapid eye movement sleep [(4.2 ±0.7)% vs.(5.3 ±1.3)%] and lower MMSE score [(22.6 ± 1.2) vs.(27.3 ±0.6)], the differences were statistically significant ( P <0.01);severe group patients'memory [(1.2 ± 0.4) vs.(2.2 ±0.5)],attention[(2.5 ±0.9) vs.(3.4 ±1.1)] and recall [(1.2 ±0.7) vs.(2.4 ±0.3)] were signifi-cantly decreased, the differences were statistically significant ( P <0.01);negative correlation with cognitive function score questionnaire ( r =-0.69, P <0.01); its predicted cognitive dysfunction in the sensitivity was 82.4%, specificity was 65.8%, the area under the curve was 0.72 (95% CI 0.61-0 .82, P <0.01).Conclusion In severe OSAHS patients, STOP-Bang questionnaire results was significantly related to cognitive function ,has some predictive value of cognitive function .%目的：研究STOP-Bang问卷与中重度阻塞性睡眠呼吸暂停低通气综合征（ OSAHS ）患者认知功能的关系，以探讨其临床应用价值。方法纳入经多导睡眠监测确诊的中重度OSAHS患者94例，根据STOP-Bang问卷将患者分为重度组（44例）和中度组（50例），并用简易智能状态量表（MMSE）评价患者的认知功能，运用Pearson相关分析和ROC曲线评价STOP-Bang问卷结果与认知功能的关系。结果与中度组患者比较，重度组患者高血压比例较高（59 z．1％vs．36．0％， P ＝0．03），体质量指数[（30．3±2．5） kg/m2 vs．（28．5±1．7） kg/m2]、呼吸暂停低通气指数[（51．2±2．4）次/h vs．（26．5±3．5）次/h]和STOP-Bang总得分较高（5．6±1．2 vs．2．3±0．6），而最低氧饱和度[（62．7±4．6）％vs．（78．2±3．8）％]、快眼动睡眠比例[（4．2±0．7）％vs．（5．3±1．3）％]和MMSE评分较低[（22．6±1．2）分vs．（27．3±0．6）分]，差异均有统计学意义（ P ＜0．01）；重度组患者的记忆力[（1．2±0．4）分 vs．（2．2±0．5）分]、注意力[（2．5±0．9）分vs．（3．4±1．1）分]和回忆力[（1．2±0．7）分 vs．（2．4±0．3）分]评分均显著下降，差异均有统计学意义（ P ＜0．01）；STOP-Bang问卷得分与认知功能呈负相关（ r ＝-0．69， P ＜0．01）；其预测认知功能障碍的敏感度为82．4％，特异度为65．8％，曲线下面积为0．72（95％CI 0．61～0．82， P ＜0．01）。结论在中重度OSAHS患者中，STOP-Bang问卷结果与患者的认知功能明显相关，对认知功能具有一定的预测价值。
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