Objective To evaluate the efficacy and safety of Lianhuaqingwen capsule in the treatment of acute upper respiratory infection and observe the effect on interferon gamma ( IFN-γ) of patients .Methods 203 cases of acute upper re-spiratory tract infection were randomly divided into two groups , treatment group of 101 cases (oral Lianhuaqingwen capsules), 102 cases in the control group given azithromycin tablets .To compare the efficacy of two groups , while the two groups were each randomly selected 20 cases of venous blood before and after each treatment , the application of ELISA kits to detect the concentration of serum IFN-γ.Results Overall efficacy in the treatment group effectiveness , efficiency and the temperature drops various clinical symptoms and signs of improvement rates were higher , two groups of patients in the prevalence of serum IFNγlevels were significantly higher , decreased significantly after treatment , with the treatment group decreased more signifi-cantly ( P <0.05).After treatment, two group patients'WBC and neutrophil percentage were significantly decreased ( P <0.05), but between the two groups , the difference was not statistically significant ( P >0.05).The incidence of adverse re-actions was not significant difference ( P >0.05 ) .Conclusion Lianhuaqingwen capsule can relieve a variety of clinical symptoms of acute upper respiratory tract infection , and have some anti-inflammatory antiviral activity .%目的：评价连花清瘟胶囊治疗急性上呼吸道感染临床疗效及其对干扰素γ（ IFN-γ）的影响。方法急性上呼吸道感染患者203例随机分为2组，治疗组101例口服连花清瘟胶囊，对照组102例给予阿奇霉素片。观察比较2组的疗效，同时2组患者各随机抽取20例于治疗前后各抽取静脉血，应用ELISA试剂盒检测其血清IFN-γ的浓度。结果治疗组在总体疗效有效率，体温下降有效率和各临床症状体征改善率方面均高于对照组，2组患者在患病后其血清IFN-γ含量均明显升高，治疗后明显下降，且治疗组下降更明显，均具有统计学意义（ P ＜0妸．05）。2组患者治疗后白细胞总数和中性粒细胞比例均显著下降（ P ＜0．05），但2组间比较，差异均无统计学意义（ P ＞0．05）。2组不良反应发生率差异无统计学意义（ P ＞0．05）。结论连花清瘟胶囊可缓解急性上呼吸道感染的各种临床症状，并有一定的抗炎抗病毒作用。
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