支气管哮喘的表型及内型研究进展

摘要

Bronchial asthma is a heterogeneous disease , which has complex pathogenesis , genetics and molecular mechanism.In recent years, aimed at the heterogeneity of asthma , researches about asthma phenotypes and endotypes are be -ing carried out, which will help diagnose, manage and treat asthma.In addition, individual treatment strategies , which based on the researches, will contribute to enhancing the curative effect , decreasing acute episode and reducing the mortality .%支气管哮喘是一种异质性疾病，造成这种异质性的原因是哮喘复杂多样的发病机制、遗传学及分子机制。近年来，针对哮喘的异质性，逐渐开展了对其表型（phenotypes）和内型（endotypes）的研究，这将有助于哮喘的诊断、管理及制定个体化治疗方案，对提高哮喘疗效、减少急性发作及降低病死率具有重要意义。