Phenotypes and Endophenotypes: Foundations for Genetic Studies of Nicotine Use and Dependence. NCI Tobacco Control Monograph Series No. 20

摘要

;Contents: Figures and Tables; Foreword; Message from the Series Editor; Acknowledgments; Acronyms and Abbreviations and Part 1- Overview: Overview and Conclusions; Status of Genetic Studies of Nicotine Dependence and Part 2- Theoretical Considerations: The Nicotine-Dependence Phenotype; Translating Theoretical Perspectives and Extant Data into Recommendations for Genetic Mapping; Mouse Models and the Genetics of Nicotine Dependence and Part 3- Developmental Trajectories of Tobacco Use and Their Relation to Tobacco Dependence: Developmental Trajectories of Cigarette Smoking from Adolescence to Adulthood; Genetic Modeling of Tobacco Use Behavior and Trajectories; Trajectories of Tobacco Use from Adolescence to Adulthood: Are the Most Informative Phenotypes Tobacco Specific and Part 4- Endophenotypes: Endophenotypes for Nicotine-Dependence Risk at or before Initial Nicotine Exposure; Nicotine-Dependence Endophenotypes in Chronic Smokers and Part 5- Epidemiological and Methodological Considerations: Epidemiological Analysis of Variation in Phenotypic Definitions: A Proof of Concept Using an Example of a Cessation Phenotype; Incorporating Social Context into Genetic Studies of Nicotine Dependence; Using Ontologies in Hierarchical Modeling of Genes and Exposure in Biological Pathways and Part 6- Future Directions: and Future Directions.