多囊卵巢综合征合并代谢综合征与脂质蓄积指数的相关性分析

摘要

目的 分析多囊卵巢综合征患者(PCOS)合并代谢综合征(MS)与脂质蓄积指数(LAP)的相关性,为PCOS合并MS的诊断提供临床依据.方法 选取2014年1月-2016年12月广东省高州市人民医院内分泌科收治PCOS患者141例为研究对象,其中合并MS 48例(观察组);未合并MS 93例(对照组).收集患者腰围(WC)、体质量指数(BMI),检测血糖、血脂、胰岛素、性激素水平,计算胰岛素抵抗指数(HOMA-IR);分析2组患者LAP水平与其他指标的相关性.结果 观察组LAP水平高于对照组(t =-17.908,P =0.000);观察组患者LAP水平与WC、收缩压(SBP)、舒张压(DBP)、空腹血糖(FPG)、餐后2 h血糖(2 hPG)、三酰甘油(TG)及HOMA-IR呈显著正相关(r =0.917、0.624、0.539、0.504、0.567、0.946,P <0.01),与高密度脂蛋白胆固醇(HDL-C)呈显著负相关(r =-0.703,P= 0.000).LAP是诊断PCOS合并MS的有效指标,在LAP > 50.7时具有最大的特异度(0.971)与灵敏度(0.939).结论 PCOS患者LAP水平与MS的发生有着密切的相关性,LAP对于PCOS合并MS的预防及诊断具有重要的临床价值.%Objective To investigate the relationship between lipid accumulation index(LAP)and metabolic syndrome(MS)in patients with polycystic ovary syndrome(PCOS)and to provide clinical evidence for the prevention and diagnosis of PCOS combined with MS.Methods One hundred and forty one cases of PCOS patients who treated in our hospital during January 2014 to December 2016 were chosen as study objects.Among them,48 cases were combined with MS and they were enrolled in the study group;93 cases who without MS were enrolled in the control group.The LAP and other indexes in two groups were analyzed.Results The LAP level of the observation group was higher than that of control group(t=-17.908,P=0.000);PCOS and MS patients'' LAP and WC,systolic blood pressure(SBP),diastolic blood pressure(DBP),fasting blood glucose(FPG)2 h postprandial blood glucose(2 h PG),three glycerol(TG)showed a positive correlation with HOMA and IR(r=0.917,r=0.624,r=0.539,r=0.504,r=0.567,r=0.946,P<0.01),and was negatively correlated high density lipoprotein cholesterol(HDL-C)(r=-0.703,P=0.000).LAP is an effective index for diagnosing PCOS combined with MS,with the greatest specificity(0.971)and sensitivity(0.939)at LAP > 50.7.Conclusion The level of LAP in patients with PCOS is closely related to the occurrence of MS and LAP has an important clinical value in the prevention and diagnosis of PCOS combined with MS.