TNF-α在胃癌发生发展中的作用及治疗研究进展

摘要

Chronic inflammation is closely related with a variety of cancer, among which, gastric cancer (GC) is a typical one. Tumor necrosis factor α(TNF-α) plays an important role in chronic inflammation mediated gastric carcinogenesis. TNF-α is a multiple functional cytokine,activating various signaling pathways by binding to receptors. It can regulate inflam-mation,immunity,cell apoptosis or survival. Many studies have shown TNF-α is involved in gastric carcinogenesis,cell pro-liferation,invasion,metastasis,epithelial mesenchymal transformation and neovascularization. TNF-α is expected to become a biomarker for diagnosing and evaluating the prognosis of GC,and provides a new target for GC treatment. In addition,due to its cytotoxic effect at high dose,TNF-α can be used as a drug in conjunction with gastric cancer targeted small molecule pep-tide. This article reviewed the effect of TNF-α on gastric cancer development,and provide a new idea for the prevention and treatment of GC.%慢性炎性反应与多种恶性肿瘤的发生密切相关,胃癌就是典型之一.肿瘤坏死因子α(TNF-α)在慢性炎性反应介导胃癌发生的过程中发挥了重要作用.TNF-α是具有多种功能的细胞因子,通过结合到受体上激活多条信号通路,调控炎性反应、免疫、细胞凋亡或存活.大量研究证实TNF-α参与了胃癌发生、细胞增殖、胃癌侵袭和转移、上皮间质转化、新生血管形成等多个病理过程,有望成为胃癌诊断和评估治疗预后的生物标志物,为胃癌治疗提供新的靶点.同时,TNF-α可作为治疗胃癌的药物,与具有胃癌导向的小分子肽联合应用发挥细胞毒性作用.现综述TNF-α对胃癌发生发展的影响,为胃癌预防和治疗提供新的思路.