2型糖尿病患者血糖、胰岛素抵抗和β细胞功能对CA199水平的影响

摘要

目的 探讨T2DM患者CA199水平与血糖、IR和胰岛β细胞功能之间的关系.方法 人选T2DM患者165例,分别以HbA1c 10.1％、FPG 8.31 mmol/L、胰岛素抵抗指数(HOMA-IR)2.7、胰岛功能指数(HOMA-islet) 22.1为界,分为高HbA1 c组(HH组)和低HbA1 c组(LH组)；高FPG组(HF组)和低FPG组(LF组)；IR组和胰岛素敏感组(SR组)；胰岛β细胞功能正常组(BN组)和胰岛β细胞功能减退组(BW组),比较各组CA199水平.结果 HH组CA199水平高于LH组(26.75 vs 16.68U/ml,P＜0.05).Spearman相关研究显示,CA199与HbA1c、FPG呈正相关(P＜0.05),与IR、胰岛β细胞功能无相关性(P＞0.05)；多元逐步回归分析显示,HbA1c是CA199的主要影响因素.结论 T2DM患者CA199水平与血糖状态密切相关.%Objective To investigate the relations of CA199 level with blood glucose, insulin resistance, and β cell function in patients with type 2 diabetes mellitus. Methods The 165 hospitalized patients with type 2 diabetes were enrolled. They were divided into high glycosylated hemoglobin group (HH) and low glycosylated hemoglobin group (LH) at the cut level of HbA1c 10. 1%, into high fasting blood glucose group (HF) and low fasting blood glucose group (LF) at the cut level of FPG 8. 31 mmol/L, into insulin resistance group (IR) and insulin sensitivity group (SR) at the cut level of HOMA-IR 2. 7, and into normal (3 cell function group (BN) and low β cell function group (BW) at the cut level of HOMA-β 22.1. The CA199 level among the four groups was compared. Results The CA199 level of the HH group at 26. 75 U/ml was significantly higher than the LH group at 16. 68 U/ml (P<0. 05). Spearman relation analysis showed that the CA199 level was positively correlates with HbA1 c and FPG (P <0. 05), but not correlated with IR and β cell function (P>0. 05). Multiple stepwise regression analysis showed that HbA1c was the main risk factor for CA199. Conclusion The CA199 level in patients with type 2 diabetes closely correlates with the state of blood glucose.