噻唑烷二酮类药物对2型糖尿病患者骨代谢的影响及其机制

摘要

Thiazolidinediones (TZDs),selective agonists of peroxisome proliferator-activated receptor gamma,are oral anti-diabetic drugs.Several large-scale clinical trials have reported that TZDs may contribute to decreased bone mineral density and increased risk of fracture.In this article,the effects and mechanisms of thiazolidinediones on bone metabolism in the patients with type 2 diabetes are reviewed in details.%TZDs类药物是近年来常用的一类口服降糖药,其可能会对糖尿病患者的骨代谢产生不良影响,使骨密度下降,甚至导致骨折风险增加.本文就TZDs类药物对糖尿病患者骨代谢的影响及其可能机制进行综述.