血清维生素D水平与肥胖及代谢异常关系的研究

摘要

Objective To investigate the relationship of serum vitamin D with obesity and metabolic abnormalities. Methods A total of 300 adults who visited Wuhan Union Hospital for a general health checkup from January to December 2009 participated in the study- They were divided into hypovitaminosis D group and control group, 150 in each, according to their serum 25-(OH) D levels. The comparisons of somatometric index, blood pressure, plasma glucose, blood lipid, and the related metabolic diseases of the two groups were carried out The serum 25-(OH)D concentration was detected with Enzyme-linked immunosorbent assay. Result In the hypovitaminosis D group, the levels of BMI, TG, and LDL were all higher than those in the control group (all P<0.05). There was no significant difference in WC, SBP, DBP, FBG, TC, and HDL between the two groups. Compared with the control group, the prevalence of obesity (P= 0.015), central obesity (P= 0.004) and hypertension (P = 0.002) were higher in the hypovitaminosis D group. Conclusion Hypovitaminosis D is associated with obesity and metabolic abnormalities, and LDL-C is its independent risk factor.%目的 探讨血清VitD水平与肥胖及代谢异常的关系. 方法 300例受试者均为2009年1～12月于我院进行健康体检的非体力劳动者.根据血清25-(OH)D水平将受试者分为VitD下降(HD)组和对照(NC)组,对两组患者BMI、血压、血脂、血糖水平及相关代谢疾病的患病情况进行比较.血清25-(OH)D水平采用ELISA检测. 结果 HD组BMI、TG、LDL-C均高于NC组(P均＜0.05),两组WC、SBP、DBP、FPG、TC、HDL-C差异无统计学意义.与NC组相比,HD组肥胖、腹型肥胖及高血压患病率也显著增高(P值分别为0.015、0.004、0.002). 结论 血清VitD水平下降与肥胖及其代谢异常密切相关,血LDL-C是血VitD下降的独立危险因素.