目的 探讨经皮氧分压(TcPO2)在T2DM合并周围神经病变(DPN)患者的变化及临床意义.方法 选取2014年10月至2015年9月于江苏省连云港市第一人民医院内分泌科住院的T2DM患者222例,采用TCM400经皮氧分压检测仪检测50名健康对照(NC)组和222例T2DM患者仰卧位足背TcPO2值,依据神经传导速度(NCV)将T2DM患者分为DPN组102例和非DNP(NDPN)组120例,分析各组一般临床资料.结果 与NC组和NDPN组比较,DPN组仰卧位TcPO2值降低,与病程、多伦多神经病变评分(TCSS)、HbA1 c、SUA、FPG、NCV呈正相关.与正常TcPO2组比较,低TcPO2组DPN患者增加,运动和感觉神经NCV降低.Logistic回归分析显示,TcPO2是DPN的独立危险因素.结论 DPN患者仰卧位TcPO2降低,是DPN发生发展的危险因素,可能有助于DPN的早期诊断.%Objective To evaluate the transcutaneous oxygen pressure (TcPO2 )and its clinical significance in patients with type 2 diabetic peripheral neuropathy (DPN). Methods A total of 222 hospitalized patients with type 2 diabetes mellitus (T2DM)from the Department of endocrinology of Lianyungang First People's Hospital in Jiangsu Province were enrolled in this study from October 2014 to September 2015.And 50 healthy controls were also selected in this study as control group (NC group). TcPO2 was tested in supine position in all the subjects by TCM400 TcPO2 detector. Patients with T2DM then were divided into two groups according to Nerve conduction velocity (NCV):DPN group (n = 102) and non-DPN group (NDPN group,n = 120).Anthropometric and metabolic parameters were assessed in each group. Results TcPO2 in supine positionwas lower in DPN group than in NC and NDPN group. TcPO2 was positively correlated with diabetes duration,TCSS scores,HbA1 c,SUA,FPG and NCV.Compared with normal TcPO2 group,the prevalence of DPN was increasedin low TcPO2 group,while NCV of motor nerve and sensory nerve were decreasedin low TcPO2 group.Logistic analysis showed that TcPO2 was an independent risk factor for DPN. Conclusion TcPO2 in supine position was decreased in patients with DPN,and is a risk factor for DPN,which may provides valuable information for DPN diagnosis.
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