急性胰腺炎导致多器官功能障碍综合征的早期危险因素研究

摘要

Objective To invesligale the early risk factors on multiple organ dysfunclion syndrome caused by acute pancreatitis. Methods Clinical data were collected from 135 hospitalized patients of acute pancreatitis admitted from June 2008 to June 2011, some factors in the early time (within 48 h) after the onset of acute pancreatitis were statistically analyzed by univariate and multivariate binary logistic regression analysis. Results 21 patients suffered from multiple organ dysfunction syndrome in the 135 cases( 15. 6% ) . 11 factors such as age had statistics differences (P < 0. 05 ) by univariate analysis, in which serum albumin < 30 g/L ( P = 0. 018, OR = 9. 221 ) , creatinine > 120 μmol/L ( P = 0. 001, OR = 21. 042 ) , lactate dehydrogenase > 400 U/L ( P = 0. 025 , OR =7.469) were the independent early risk factors on multiple organ dysfunction syndrome caused by acute pancreatitis proved by multivariate analysis. Conclusion More attention should be paid to the patients of acute pancreatitis with low level of serum albumin, high level of creatinine or high level of lactate dehydrogenase in the early time( within 48 h) , which had more risk to suffer from multiple organ dysfunction syndrome. Effective measures should be taken to reduce mortality as soon as possible.%目的 研究急性胰腺炎(AP)导致多器官功能障碍综合征(MODS)的早期危险因素.方法 收集2008-06～2011-06我院收治的135例AP住院患者临床资料,对发病早期(48 h内)若干指标进行单因素、多因素二分类Logistic回归分析.结果 135例患者,发生多器官功能障碍综合征21例(15.6%),单因素分析得到年龄等11个因素有统计学意义(P<0.05),多因素分析得到血清白蛋白<30 g/L(P=0.018,OR=9.221)、血清肌酐>120 μmol/L(P=0.001,OR=21.042)、乳酸脱氢酶>400 U/L(P=0.025,OR=7.469)为AP导致MODS的早期独立危险因素.结论 AP患者,若发病早期(48 h内)出现血清白蛋白降低、肌酐或乳酸脱氢酶升高时容易出现MODS,需高度注视,及早采取有效措施降低死亡率.