帕金森病康复治疗及其作用机制研究进展

摘要

Parkinson's disease (PD) is characterized by the progressive degeneration of dopaminergic neurons in substantia nigra pars compacta.Rehabilitation therapy can delay the development of disease,improve motor symptoms and non-motor symptoms (NMS),and consequently improve the activities of daily living (ADL) in patients with PD.The mechanism of rehabilitation improving the symptoms of PD is very complex,involving a variety of molecular mechanisms.Thus,this review will focus on the effect of rehabilitation therapy on PD and the underlying molecular mechanism including neurotransmitters,trophic factors,synaptic plasticity and immune system.%帕金森病是渐进性黑质致密部多巴胺能神经元退行性变导致的疾病,康复治疗可以延缓病情进展,改善运动症状和非运动症状,提高患者日常生活活动能力.康复训练改善帕金森病症状的机制复杂,涉及多种分子学机制,本文系统阐述康复训练对帕金森病症状的改善作用,以及神经递质、营养因子、突触可塑性和免疫系统等方面的分子学机制.