基于多基因表达水平的乳腺癌预后预测研究进展*

摘要

乳腺癌是女性最常见的恶性肿瘤之一。依据目前的临床预后预测指标和诊疗规范，70%淋巴结阴性和30%淋巴结阳性乳腺癌患者在术后5～10年内未发生远处转移，但却遭受不必要的化疗副作用。基于高转移潜能的肿瘤细胞中一系列转移相关基因的表达异常，多基因表达水平检测作为临床病理因素的补充已成功应用于乳腺癌患者预后预测。本文将对基于基因表达谱和RT-QPCR方法的多基因表达水平的乳腺癌患者预后预测方法和预测能力的研究进展进行综述。%Breast cancer is one of the most common cancers in women. Current clinical prognostic indicators and practice guide-lines show that almost 70% of node-negative and 30% of lymph node-positive breast cancer patients can survive 5-10 years without dis-tant metastasis after surgery. Patients also unnecessarily suffer the side effects of chemotherapy. Assays on multi-gene expression levels as prognosis prediction indicators have been successfully used to predict the prognosis of breast cancer patients because of the abnor-mal expression levels of a series of metastasis-related genes in cancer cells with high metastatic potential. In this review, we highlight the progress of research on predicting breast cancer prognosis based on multi-gene expression levels detected by microarray and qRT-PCR methods.