化疗、分子靶向治疗以及内分泌治疗是肿瘤内科治疗的重要组成部分，各种抗肿瘤药物的出现虽为肿瘤患者带来生存获益但均未克服耐药性的问题。放疗为肿瘤常规治疗的三大手段之一，约2/3肿瘤患者在其病程的某一阶段需要接受放疗，放疗抗拒是目前制约放疗疗效的重要原因。上皮间质转化（epithelial-mesenchymal transition ，EMT）是上皮细胞向间质细胞转化的过程，在胚胎发育、肿瘤的侵袭转移中的作用已被大量研究，与肿瘤的治疗抗拒也存在着密切的联系，EMT与肿瘤治疗抗拒之间关系的研究将有望克服耐药性及放疗抗拒的发生，提高疗效，使更多的患者得以治愈。本文将就EMT与肿瘤治疗抗拒相关机制的研究进展进行综述。%Chemotherapy, molecular targeted therapy, and hormonal therapy are essential components of medical oncology. Al-though cancer patients significantly benefit from the emergence of various new anticancer drugs, none of these treatments can directly address drug resistance. Radiation therapy is one of the three conventional cancer treatment methods. Nearly two-thirds of cancer pa-tients accept radiation therapy during treatment. However, radiation resistance is a significant barrier affecting the therapeutic effect of this procedure. Epithelial–mesenchymal transition (EMT) is a biologic process that enables a polarized epithelial cell to undergo multi-ple biochemical changes. These changes enable the cell to assume the functions of a mesenchymal cell phenotype. These functions have been extensively studied and are related to embryogenesis, tumor invasiveness, and metastasis. In recent years, increasing evidence sug-gests that EMT is closely linked with tumor treatment resistance. The study of the relation between EMT and tumor treatment resistance is expected to contribute to the prevention of drug resistance and radiation resistance and thus improve treatment efficacy to provide benefit to cancer patients. This article explores this issue.
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