转录因子GLI1在肿瘤发生与侵袭转移作用中的机制

摘要

哺乳动物Hedgehog基因家族包括3个成员：Sonic hedgehog（SHH）、Desert hedgehog（DHH）和Indian hedgehog（IHH）。SHH信号通路主要由分泌型信号糖蛋白SHH配体、跨膜蛋白受体PTCH和另一跨膜蛋白SMO的复合物，以及3种GLI蛋白的下游转录因子GLI1、GLI2、GLI3组成。作为最经典的信号通路之一，SHH信号通路在胚胎发生、发育和组织更新等过程中发挥至关重要作用。GLI1是该通路中最重要转录因子之一，其异常活化与纤维化修复、肿瘤的发生发展与侵袭转移、肿瘤耐药和预后等密切相关。本文就GLI1与肿瘤发生与侵袭转移作用机制进行综述。%The mammalian animal gene family Hedgehog includes three members, namely, Sonic hedgehog (SHH), Desert hedgehog, and Indian hedgehog. As one of the classical signaling pathways, the SHH signaling pathway has a crucial function in the processes of embryogenesis, development, and tissue regeneration. GLI1 is one of the most important transcription factors in this path-way. Abnormal GLI1 activation is closely related to fibrosis repair, tumorigenesis, invasion and metastasis of tumors, and tumor drug re-sistance and prognosis. This article briefly describes the relationship among GLI1, tumorigenesis, and tumor development.